Acridinedione Dyes Interact with Proteins

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Author work represents photophysical with a molecular docking approach to investigate the interaction of acridinedione dyes with proteins in aqueous solutions. Acridinedione dyes are widely used as fluorescent dyes, and their interaction with proteins has implications in various fields, including drug discovery, enzyme inhibitors and molecular recognition. It involves the utilization of fluorescence spectroscopy to examine the interaction of acridinedione dyes with adenine, amino acids, and globular proteins. It also involves the employment of computational methods, including molecular docking, to investigate the protein-ligand interaction and ligand binding. The results revealed that acridinedione dyes strongly bind to proteins through non-covalent interactions, forming stable protein-ligand complexes. The interaction between acridinedione dyes and proteins was also explored in terms of protein structure, conformational changes and dynamics. It was found that the interaction induced conformational changes in the proteins, which affected their function and folding. The author also investigated the thermodynamics of the interaction, revealing that the binding of acridinedione dyes to proteins is driven by enthalpy and entropy changes. These findings shed light on the importance of understanding the interaction between acridinedione dyes and proteins in biochemistry and biophysics. The knowledge gained from this study can aid in the design of new drugs and enzyme inhibitors. Additionally, the study highlights the significance of spectroscopic techniques, such as fluorescence resonance energy transfer and surface plasmon resonance, in investigating protein-ligand recognition and activity. In conclusion, this work on the interaction of acridinedione dyes with proteins provides insight into the nature of the protein-ligand interaction and its implications in various fields. This book demonstrates the importance of understanding the chemical biology and chemical structure of the interaction and highlights the potential of acridinedione dyes as a tool for investigating biomolecular interactions.