Annual Report, 1986 (Classic Reprint)

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Excerpt from Annual Report, 1986Pharmacokinetic models are developed for the distribution and disposition of ntaminants, and endogenous metabolites in animals and provide at plausible set of equations that can be used to extrapolate data from animals to man and thereby improve chemotherapy and risk assessment. Emphasis has been placed on regional drug administration, and this has led to the development of spatially distributed models of drug transport in tissue. These analyses have provided considerable insight into the penetration depths of drugs administered intraperitoneally or by infusion into the brain. Pharmacokinetic theory which was developed for intra-arterial drug administration combined with extracorporeal treatment of venous drainage has been furuunrvalidated in the clinic. Preliminary results have shown the feasibility of documenting appropriate vascular drainage with indocyanine green. Interspecies scaling of regional drug administration has been explored, and a clear allometric basis has been elaborated.About the PublisherForgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.comThis book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully, any imperfections that remain are intentionally left to preserve the state of such historical works.