Apoptosis in Neurobiology

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The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death-has created an urgent need for reliable documentation of the different approaches to and methods of studying the various aspects of the field. Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated neuroscientist intellectual and practical access to the study of apoptosis, with special consideration to the nervous system. The first section concentrates on conceptual approaches to the study of apoptosis in neurobiology and its significance to the nervous system. The second section provides a user-friendly approach to methods and techniques in the study of apoptosis, including, where appropriate, as applied to neurobiology. TOC:Preface, Y.A. Hannun and R.-M. Boustany.- Diseases and Concepts: Introduction: Occurrence, Mechanisms, and Role of Apoptosis in Neurobiology and in Neurologic Disorders, R.-M. Boustany and Y.A. Hannun.- Cell Death in the Developing Nervous System, V. Narayanan.- Neurodegenerative Disorders, D. Schmechel.- Neurooncology and Cancer Therapy, N.F. Schor.- Human Immunodeficiency Virus Type I, H.A. Gelbard.- The Role of Proteases in Neuronal Apoptosis, S. Kaufmann.- Molecular Mechanisms in the Activation of Apoptotic and Anti-Apoptotic Pathways by Ceramide, R. Dobrowsky.- Methods: Assessment of Cell Viability and Histochemical Methods in Apoptosis, K. Puranam and R.-M. Boustany.- Assessment of Ultrastructural Changes Associated with Apoptosis, D. Schmechel.- Flow Cytometry in the Study of Apoptosis, M. Smyth.- Methods Used to Study Protease Activation During Apoptosis, S. Kaufmann.- Qualitative and Quantitative Methods for the Measurement of Ceramide, R. Dobrowsky.- In Vivo Neuronal Targeting of Genes, A. Amalfitano.