Asthma

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Timely research on the causes and mechanisms behind the dramatic increase of asthma in the United States and other nations - to epidemic proportions - is presented in this volume. Investigators heading up eight research groups in asthma and/or allergy present their most recent findings, funded by the Center for Indoor Air Research. In addition to the work underway and discussions/suggestions on present research problems, ASTHMA: Causes and Mechanisms provides a chapter on the causes of asthma - and the reasons for its recent spread, so hotly discussed in the current literature. Researchers in the fields of asthma and allergy, health care providers, and others who follow research in either of these two developing areas will benefit from this book. The book is written at the level of one investigator to another. TOC:The Rising Prevalence and Severity of Asthma in Western Society: Are the Causes of Asthma the Causes of the Increase?- Viral Modulation of Airway Inflammation.- The Risk of Developing Asthma During Childhood.- Loss of M2 Mascarinic Receptor Function and Expression in Airway Disease.- Role of CD4+ T Cells in the Development of Aeroallergen-Induced Allergic Inflammation.- Modified Recombinant Allergens for Immunotherapy.- Cockroach-Sensitive Guinea Pig Asthma: A Model for Indoor Environmental Asthma.- The Effects of Environmental Tobacco Smoke on Asthma: Studies With a Dynamic Exposure Chamber.- The Role of Exposure to Endotoxin in Potentiating Airway Reactivity.- The Role of Genetics and the Indoor Environment on Asthma in the Urban and Rural Setting.- Genes and the Environment in Asthma: A Changing Quotient.