Basic, Clinical and Surgical Pancreatology

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In September 2007, several experts in the field of pancreatic pathophysiology, awarded by NATO Science Committee, met in Tashkent, Uzbekistan, to present their most recent data and discuss about basic, genetic, clinical and surgical aspects of pancreatic diseases. In basic research, the implication of pancreatic stress proteins in acute pancreatitis and pancreatic cancer and their possible role as therapeutic targets were reported. Also, very original results showing the unexpected role of lipids as nefast mediators during acute pancreatitis were described. Gene screening strategies allowing detection of the genes responsible for gemcitabine resistance of pancreatic cancer cells were presented. They led to the selection of several target genes, in order to suppress the resistance of cells to gemcitabine treatment. The mechanism by which tetrahydrocannabinol is anti-tumoral in pancreatic cancer cells was presented and the use of THC as a promising new therapeutic agent was discussed. Genetic data were shown concerning hundreds of families with hereditary chronic pancreatitis and their possible role in the pathogenesis of the disease was analyzed. Another very original study addressed the prevention and treatment of pancreatic diseases with diet. In clinical research, convincing data about the use of endoscopic sphincterotomy in the management of acute biliary pancreatitis were presented. Finally, most recent consensus about indications for surgery in acute necrotizing pancreatitis were presented, based on the experience of a Center highly specialized in pancreatic diseases. TOC:Preface.- Heat Shock Proteins in Pancreatic Diseases.- Cellular stress in acute pancreatitis.- Systemic inflammatory effects of acute pancreatitis : Effects of lipid mediators.- Gemcitabine changes the gene expression in human pancreatic cancer cells: search for new therapeutic molecular targets.- Cannabinoids as potential antitumoral agents in pancreatic cancer.- Pathogenesis of Chronic Pancreatitis with Special Emphasis on Genes.- Bioecological control of disease, especially pancreatic disease.- The role of endoscopic sphincterotomy in the management of acute biliary pancreatitis.- Indication for surgery in acute necrotizing pancreatitis.