Biophysical and Structural Aspects of Bioenergetics

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Bioenergetics is a term used to describe the events of primary energy transduction in biology. The field has seen tremendous advances in recent years thanks to developments in the biophysical and computational techniques used to solve the three-dimensional structures of the membrane-bound proteins, which often act as catalysts in these reactions. This has enabled researchers to bring, otherwise static, structures to life and decipher the dynamic function of these intriguing systems. "Biophysical and Structural Aspects of Bioenergetics" brings together contributions from internationally respected experts, all of whom helped shape and develop the field of bioenergetics. It provides a representative snapshot of the very latest key developments in this multidisciplinary subject, with an emphasis on molecular structure, and how this changes during the bioenergetic function. Offering a comprehensive overview of the current state of the art, and complete with extensive citations in each chapter, this book is the ideal reference for both biochemists and biophysicists studying this fascinating topic. TOC:Mårten Wikström: Preface.- Robert B Gennis: Principles of molecular bioenergetics and the proton pump of cytochrome oxidase.- Martyn A Sharpe, Ling Qin and Shelagh Ferguson-Miller: Proton entry, exit and pathways in cytochrome oxidase: Insight from 'conserved' water.- Shinya Yoshikawa: Structural chemical studies on the reaction mechanism of cytochrome c oxidase.- Peter Brzezinski and Pia Ädelroth: Mechanisms of redox-coupled proton pumping by respiratory oxidases.- Per E M Siegbahn and Margareta R A Blomberg: Quantum chemical models of O2 bond cleavage and proton pumping in cytochrome oxidase.- Antony R Crofts: the bc1 complex: what is there left to argue about?.- Stefan Kerscher, Volker Zickermann, Klaus Zwicker and Ulrich Brandt: Insights into the mechanism of mitochondrial Complex I from its distant relatives, the [NiFe] hydrogenases.- Judy Hirst: Current knowledge about the mechanism of energy transduction by respiratory Complex I, .- Kristina N Ferreira and So Iwata: Structure of Photosystem II from Thermosynechococcus elongates.- Janos K Lanyi: A structural view of proton transport by bacteriorhodopsin.- Joachim Heberle: The dynamics of proton transfer across bacteriorhodopsin explored by FT-IR spectroscopy.- Colin A Wraight: Intraprotein proton transfer - concepts and realities from the bacterial photosynthetic reaction center.- Peter Rich and Masayo Iwaki: Infrared protein spectroscopy as a tool to study protonation reactions within proteins.- John E Walker and Jonathan R Gledhill: Inhibitors of mitochondrial F1-ATPase.- H Ronald Kaback: The passion of the permease.- J Baz Jackson, Scott A White and T Harma C Brondijk: Hydride transfer and proton translocation by nicotinamide nucleotide transhydrogenase.