Cancer Cell Signalling

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As our understanding of tumour biology has developed, molecules involved in disrupting normal cell signalling and driving cells towards a more cancerous phenotype have provided the basis for new drug targets, and a number of targeted biological therapies now exist for the treatment of tumours. However, many cancer patients have tumours that are either refractory to treatment, or that develop resistance. The amount of research into this area has provided a wealth of information about cross-talk between signalling pathways and compensatory signalling. The aim of this book is to introduce a number of cell signalling pathways that are both well characterised and reported to play central roles in the development of a number of different tumour types. Each chapter focuses on an individual pathway, its key components and dysregulation in tumour development, in the context of both current therapies and future strategies. The final chapter is devoted to signalling cross-talk. Interactions between signalling pathways, compensatory signalling and tumour related issues are presented so that the reader will not only develop a better appreciation for the role of signalling in disease, but also begin to understand the relevance of cross-talk. Cancer Cell Signalling will prove invaluable for advanced undergraduates and postgraduates studying and researching within this fast moving and complex field. * A focused, accessible introduction to cell signalling, its role in cancer development and implications for current and future therapeutic opportunities. * Covers the individual cell signalling pathways that are known to be involved in cancer development, and includes the cross-interactions between the pathways together with the current therapeutic approaches. * Includes colour figures throughout, to illustrate the key pathways explored within the text.