Cellular Signal Transduction in Toxicology and Pharmacology

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Provides practical approaches for informatics, big data, and complex data sets of cellular signal transduction in toxicology and pharmacology This book offers a thorough discussion of signal transduction mechanisms and approaches that can help toxicologists and pharmacologists guide future study design and data interpretation. It gives readers a solid background in signal transduction networks, while supplying the tools necessary for further research in this expanding area. These tools include a discussion of experimental design, sample handling, analytical measurement techniques, and data analysis and interpretation (including novel modeling approaches). Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation is organized hierarchically. The first four chapters describe the architecture of signaling networks-from a physical basis of understanding signaling through mechanisms, physiological response, and human disease. The last half of the book is a how-to for incorporating signal transduction research into your portfolio-from designing signal transduction studies, to measuring and monitoring signaling responses, interpreting and transforming data into useable information, and finally outlining critical future needs in signal transduction research. * Covers a topic of key interest to toxicologists as there is a growing body of research into the role of signaling mechanisms in toxicology * Features a practical focus on modern approaches like the use of informatics, big data, and complex data sets * Combines fundamentals/basics with experimental applications that can help those involved in preclinical drug studies and translational research * Includes detailed presentations of study methodology and data collection, analysis, and interpretation * Discusses tools like experimental design, sample handling, analytical measurement techniques Written for an audience with a background in biochemistry or cell biology, Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation provides a comprehensive understanding of signal transduction research that is applicable to industry, academia, and government.