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Combinatorial Chemistry
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This revolutionary method enables organic and medicinal chemists to synthesize thousands or even millions of potentially interesting compounds in a single reaction sequence. Combined with current methods of high throughput analysis, combinatorial methods have almost completely replaced the traditional step-by-step synthesis of potential drugs.
Retaining its practice-oriented approach, this new edition has been thoroughly updated to reflect recent developments in parallel synthesis, while a new chapter on screening complements the overview of combinatorial strategy and synthetic methods. The result is a handbook tailored to the needs of the industry, with almost all the authors affiliated with leading pharmaceutical companies.
From the contents:
Purification Principles in High-Speed Solution Phase Synthesis
Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Support
Cyclative Cleavage - A Versatile Concept in Solid-Phase Organic Chemistry
C-C Bond Forming Reactions
Combinatorial Synthesis of Heterocycles
Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis
Encoding Strategies for Combinatorial Libraries
Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis
Assays for High Throughput Screening in Drug Discovery
Computer-Assisted Library Design
Appendix: Cheminformatics and Web Resources for Combinatorial Chemistry
For organic and medicinal chemists, chemists in industry, and the pharmaceutical industry.
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