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  • Comparing Cell Culture and Mouse Assays for Measuring Ineffectivity of Cryptosporidium

Comparing Cell Culture and Mouse Assays for Measuring Ineffectivity of Cryptosporidium

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The objective of this research was to compare in-vitro cell culture methods with a mouse assay for measuring infectivity of Cryptosporidium parvum oocysts. The specific objectives were to (1) compare the dose response and sensitivity of cell culture and mouse assays with multiple isolates, (2) compare infectivity methods with oocysts exposed to environmental water samples, (3) determine the reproducibility and variability of the methods, and (4) compare cell culture and animal assays for assessing ozone and UV disinfection.
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