Division of Cancer Biology and Diagnosis, Annual Report, Vol. 2

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Excerpt from Division of Cancer Biology and Diagnosis, Annual Report, Vol. 2: Extramural Research Program, October 1, 1983-September 30, 1984Research in identifying and characterizing oncogenes has progressed at a rapid pace in the last year, as evidenced by the expanded list of oncogenes that have been discovered and the remarkable findings identifying previously unsuspected biological activities of some oncogene products. This information is summarized in the adjoining table. Many of the original observations suggesting tissue specificity for oncogene expression have not been confirmed, but most of the fundamental criticisms questioning the validity of oncogene assay systems have been allayed. Now it is possible to form hypotheses of how oncogenes are activated to produce transformed cellular growth. An important fact to emphasize, however, is that oncogene research has been entirely focused on genes which contribute to uncontrolled growth phenomenon. No studies in this area have addressed later events in tumor progression which lead to cellular invasion and metastasis.About the PublisherForgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.comThis book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully, any imperfections that remain are intentionally left to preserve the state of such historical works.