Engineering of Microbial Biosynthetic Pathways

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This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important bioproducts.Metabolic engineering has the potential to produce large quantities of valuable biomaterials in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various biosensors used for metabolite detection and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, biofuels, pigments, and alkaloids. It also discusses various synthetic biology tools such as genome editing, assembly, MAGE, small regulatory RNA, microfluidics, and CRISPR-Cas genome editing systems for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory challenges in the metabolic engineering of microbes.