Epigenetics of Stress and Stress Disorders

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As the known influence of epigenetic responses to pathological stress and stress related disorders increases, so does our understanding of why individuals possess different levels of resilience after experiencing the same trauma. Epigenetics of Stress and Stress Related Disorders, a new volume in the Translational Epigenetics Series, examines the epigenetic mechanisms involved in modifying DNA or gene expression following prolonged stress and/or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to the development of stress disorders. The book begins with an introduction to both genetic and psychiatric foundations, including modes of epigenetic modification and gene expression that result from stress, as well as the medical knowledge required to understand stress related disorders and resilience. From here, chapter authors discuss a range of epigenetic research techniques as applied in recent studies, including epigenome-wide association studies (EWAS) of PTSD and resilience, the possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PSTD on the health of patients. The book concludes by examining the possible effects of transgenerational stress-induced epigenetic alterations on the resilience of future offspring, the potential for epigenetic therapeutics, and public health implications.