Flexible Viruses

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The only book to summarize recent achievements in the experimental and computational analyses of structural disorder in viral proteins Over the past two decades, the hypothesis that protein function relies on precise 3D structure has been challenged by a wealth of counterexamples, showing that many intrinsically disordered proteins (IDPs) function in an entirely or partly disordered state. Despite this large body of experimental evidence of the abundance and biological relevance of IDPs in the living world, the notion of 3D structure is still deeply anchored in many scientists' minds-due mainly to a lack of focus on recent and exciting developments in IDP studies. Flexible Viruses provides the latest information on experimental and computational characterization of structural and functional properties of viral proteins endowed with disordered regions. Featuring chapters by leading research groups around the world, the book contains modern information on various aspects related to the structural and functional roles of intrinsic disorder in viral IDPs. Flexible Viruses: * Addresses debilitating diseases such as AIDS, herpes, lymphoma, and hepatitis * Covers prediction and experimental assessment of disordered regions in partial IDPs * Examines the mechanistic aspects of "folding-coupled-to-binding" * Explains the biological relevance of disordered regions and structural transitions * Analyzes the unique features of each class of viral proteins * Includes case studies from leading research groups around the world Complete with a detailed presentation of the implications of current findings for new directions in future research and disease management, Flexible Viruses is intended to stimulate and inspire scientists toward further exploration of this intriguing and very promising field.