Formulation and evaluation of ternary dispersion of curcumin

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Curcumin is a yellow-orange powder that is insoluble in water and ether but soluble in ethanol, dimethylsulfoxide, and acetone. Curcuminoids exhibit a broad spectrum of biological and pharmacological activities. Curcumin's unique ability to work through so many different pathways with its extraordinary antioxidant and anti-inflammatory attributes can have a positive influence in combating almost every known disease. In spite of high efficacy and safety, curcumin has not yet been approved as a therapeutic agent, due to the poor solubility and oral bioavailability. Aim of this work is to formulate and evaluate the ternary dispersion (Third Generation Solid Dispersion) of curcumin in order to enhance the dissolution rate by solvent evaporation method (coprecipitation method) with the use of Carrier & Poloxamer. Ternary solid dispersions avoid the drug recrystallization and thus enhance the dissolution rate than Binary solid dispersion.A ternary solid dispersion with solvent evaporation method (coprecipitation method) meets the above requirement to prepare the highly soluble curcumin preparation and comparatively cheaper product ever before.