Genotoxicity Studies of Chalconesemicarbazone derivative

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Coauthors: Dr. S.S. Pancholi, Professor & Principal has teaching experience over 18 yrs and guided several M.Pharm. and Ph.D. students. He is actively engaged in teaching, research and service to his profession. He has many national and international research publications at his credit. Mr. Dhaval M. Patel, a Young Researcher obtained his M.Pharm. degree in Pharmacology from Gujarat Technological University, Ahmedabad in 2012. This book consists of research work duly carried out by Mr. Dhaval M. Patel at Babaria Institute of Pharmacy, Vadodara. An attempt was made to assess the genotoxic or antigenotoxic potential of chalconesemicarbazone derivative (CSC) against cyclophosphamide induced genotoxicity model in mice by using bone marrow chromosomal aberration and sperm abnormality assay. CSC treatment alone is devoid of any genotoxic effect, whereas, pretreatment of CSC showed decrease in chromosomal aberration and sperm abnormalities against cyclophosphamide induced genotoxicity in mice.

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