National Institute of Arthritis and Musculoskeletal and Skin Diseases

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Excerpt from National Institute of Arthritis and Musculoskeletal and Skin Diseases: Annual Reports, Intramural Research Programs, October 1, 1990 to October 1, 1990 The pattern of crossbridge formation between the thick and thin filaments was studied in the rigor state by using low salt, high ph conditions to dissociate the thick filaments and monitoring the detailed structural changes by electronmicroscopy and X-ray diffraction. In the part of the A-band that contains only thick filaments (the H-zone) the filaments dissociated mainly into three subfilaments. In the part of the A-band where thick and thin filaments interdigitate and actomyosin crossbridges are present, the thick filaments open to form hollow rings and then numerous subfilaments. This pattern of dissociation indicates that the thick filaments are made up of three parallel subfilaments, and that the crossbridges from each subfilament are shared by at least three of the adjacent actin filaments. (barbosa, Podolsky) About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully, any imperfections that remain are intentionally left to preserve the state of such historical works.