New Insights on the Development of the Vascular System

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Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and the molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years. For example, evidence is emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Endothelial cell signaling is believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Although scientific literature covers descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis, give new insight into the mechanisms by which vessels form and regress and blood flow changes directions in the same vessels, offering powerful tools for examining the development of the vascular system. New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, as well as offering advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development.