Nutrition, Exercise and Epigenetics: Ageing Interventions

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This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3), epigenetic modification of gene expression by exercise (Chapter 5), the role of functional foods and their bioactive components in bone health (Chapter 8), and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

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