Principles and Practice of Mixtures Toxicology

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The laboratory study of toxic substances usually involves one substance at a time. In the real world, however, organisms are often exposed to a complex mixture of toxins from air, water, food or medications. Assessing the toxic effects of these mixtures requires special know-how and techniques that can account for interactions between toxins in the human body, or in a natural ecosystem. The goal of this book is to highlight basic concepts and new methods that will impact general toxicology, as well as the field of safety and risk assessment of chemicals and their mixtures. Prominent scholars and toxicologists have provided timely perspectives on how the latest science can be applied to existing problems with overviews of disciplines where significant progress has been made. Topics covered include: ¿ Mixtures Toxicology and Risk Assessment ¿ Exposure Assessment and Biomonitoring ¿ Relative Potency Factor Approach ¿ Statistical Methods and Techniques ¿ Pharmacokinetics and Pharmacodynamics Interactions ¿ Hazardous waste sites, workplace exposures, drug combinations, water disinfection by-products, endocrine active chemicals, Food Ingredients ¿ Dermal Toxicity ¿ Polycyclic Aromatic Hydrocarbons (PAHs), ¿ Polychlorinated Biphenyls (PCBs), and Nanoparticles The book is targeted to practicing and future toxicologists in academia, government and industry and will be especially useful to individuals interested in risk assessments where all these techniques come into play. The book constitutes the first comprehensive treatment of this subject in more than a decade.