Principles of CNS Drug Development

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Central Nervous System (CNS) disorders are responsible for a vast range of illnesses, including depression, schizophrenia, Parkinson's disease and Alzheimer's disease. Recent advances in areas such as genome sequencing and molecular biology have improved the potential for breakthrough treatments for these diseases, yet the drug development process for CNS disorders has remained stubbornly slow. Principles of CNS Drug Development: From Test Tube to Patient outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery. * Provides succinct background information on the major CNS diseases * Follows the development of a new drug from conception to clinical use and post-market surveillance using specific examples * Outlines the particular requirements and obstacles for CNS drugs * Highlights the primary reasons for drug failure at each stage * Addresses most likely future drug targets Principles of CNS Drug Development: From Test Tube to Patient will be an invaluable resource for students, researchers and professionals in pharmacology, neuroscience and the pharmaceutical industry.