Protein-Carbohydrate Interactions in Infectious Diseases

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Protein-carbohydrate interactions is an exciting area of research with huge potential for development and exploration. These interactions are both widespread and diverse in biological processes and many play a crucial role in cellular recognition, attachment and adhesion. This is particularly true for host-pathogen interactions that lead to infectious diseases, as the surfaces of cells and pathogens display complex carbohydrate structures and carbohydrate binding proteins on their surface. Protein-Carbohydrate Interactions in Infectious Diseases is part of the Biomolecular Science Series and provides a comprehensive overview of the subject, with contributions from leading experts in the field. Beginning with a general introduction, subsequent sections include: - Atomic basis of protein-carbohydrate Interactions - Structures and roles of Pseudomonas areuginosa lectins - Protein-carbohydrate interactions in enterobacterial infections - Retrocylcins: miniature lectins with potent antiviral activity - C-type lectin receptors that regulate pathogen recognition through the recognition of carbohydrates - Synthetic carbohydrate-based anti-malarial vaccines and glycobiology - With full colour throughout and an extensive bibliography this book is ideal for researchers interested in the area TOC:Atomic Basis of Protein-Carbohydrate Interactions. An Overview.- Mycobacterial Glycolipid and the Host: Role of Phenolic Glycolipids and Lipoarabinomannan.- Structures and Roles of Pseudomonas aeruginosa Lectins.- Protein-Carbohydrate Interactions in Enterobacterial Infections.- GM1 Glycomimetics and Bacterial Enterotoxins.- Retrocyclins: Miniature Lectins with Potent Antiviral Activity.- C-Type Lectin Receptors that Regulate Pathogen Recognition Through the Recognition of Carbohydrates.- Targeting Microbial Sialic Acid Metabolism for New Drug Development.- Synthetic Carbohydrate-Based Anti-Malarial Vaccines and Glycobiology.- Studies Towards a Rationally Designed Conjugate Vaccine for Cholera Using Synthetic Carbohydrate Antigens.- Carbohydrate Microarrays for High Throughput Analysis of Carbohydrate-Protein Interactions.