Protein-Ligand Interactions

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Frontmatter -- Preface -- Section I. General -- Letter from J. Wyman to the Members of the Symposium / Colosimo, A. / Brunori, M. / Wyman, J. -- Concerted Changes in an Allosteric Macromolecule / Colosimo, Alfredo / Brunori, Maurizio / Wyman, Jeffries -- Ligand Interactions in Globular Proteins / Weber, Gregorio -- Discussion -- Ligand Binding to Enzyme Complexes / Kirschner, Kasper / Weischet, Wolfgang / Wiskocil, Robert L. -- Discussion -- Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography / Antonini, Eraldo / Fanelli, M. Rosaria Rossi / Chiancone, Emilia -- Discussion -- Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes / Woody, Robert W. -- Discussion -- Section II. Enzymes -- The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis / Buehner, Manfred -- Discussion -- The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog / Koberstein, R. / Dieter, H. / Sund, H. -- Discussion -- The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin / Goody, R. S. / Mannherz, H. G. -- Discussion -- Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes / Pfeuffer, Thomas / Helmreich, Ernst J. M. -- Discussion -- On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 / Flossdorf, J. / Prätorius, H.-J. / Kula, M.-R. -- Discussion -- The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity / Winterhalter, K. H. / Mansouri, A. / lorio, E. E. Di -- Discussion -- Cooperative Interactions without Symmetry or Subunits / Steinhardt, Jacinto -- Discussion -- A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A / Kushnir, Tamar / Navon, Gil -- Discussion -- Section III. Repressors -- Lactose Operator Sequences and the Action of Lac Repressor / Gilbert, Walter / Gralla, Jay / Majors, John / Maxam, Allan -- Discussion -- The Active Sites of Lac Repressor / Hill, B. Müller / Fanning, T. / Geisler, N. / Gho, D. / Kania, J. / Kathmann, P. / Meissner, H. / Schlotmann, M. / Schmitz, A. / Triesch, I. / Beyreuther, K. -- Discussion -- Lac Repressor / Weber, K. / Files, J. G. / Piatt, T. / Ganem, D. / Miller, J. H. -- Discussion -- The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules / Miller, J. H. / Coulondre, C. / Schmeissner, U. / Schmitz, A. / Lu, P. -- Discussion -- Effect of Alterations in Lac Operator DNA on Repressor Binding / Bourgeois, Suzanne / Barkley, Mary D. / Jobe, Alan / Sadler, John R. / Wang, James C. -- Discussion -- Interaction of Lac Repressor with Non-Specific DNA Binding Sites / Hippel, Peter H. von / Revzin, Arnold / Gross, Carol A. / Wang, Amy C. -- Discussion -- Section IV. Receptors -- Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata / Sugiyama, H. / Popot, J.L. / Cohen, J.B. / Weber, M. / Changeux, J.P. -- Discussion -- Subunit Structure and Binding Sites of the Acetylcholine Receptor / Hucho, F. / Gordon, A. / Sund, H. -- Discussion -- Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles / McNamee, Mark G. / Weill, Cheryl L. / Karlin, Arthur -- Discussion -- Structural and Functional Studies of an Acetylcholine Receptor / Raftery, M.A. / Bode, J. / Vandlen, R. / Michaelson, D. / Deutsch, J. / Moody, T. / Ross, M.J. / Stroud, R.M. -- Discussion -- Section V. Antibodies, Drugs and Metabolites -- Antibody Combining Sites as a Model for Molecular Recognition / Pecht, I. -- Discussion -- Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis / Perkins, Harold R. / Ghuysen, Jean-Marie / Frère, Jean-Marie / Nieto, Manuel -- Discussion -- Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin / Lutz, R.A / Wiegand, U.-W. / Weder, H. G. -- Discussion -- The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution / Blauer, G. / Lavie, E. -- Discussion -- Section VI. Detergents and Electrolytes -- The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding / Steinhardt, Jacinto -- Discussion -- Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium / Yonath, J. / Blauer, G. -- Discussion -- Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins / Pohl, Fritz M. -- Discussion -- Neutral Salt Effects on the Conformational Stability of Biological Macromolecules / Hippel, Peter H. von -- Discussion -- Concluding Remarks / Hippel, Peter H. von -- Index of Contributors -- Subject Index -- Backmatter