Protein Misfolding Diseases

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An in-depth look at new discoveries in protein misfolding disease research Protein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow. Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases. With a systematic overview, Protein Misfolding Diseases: * Emphasizes therapeutics in an amyloid disease context, which helps bridge the gap between basic science and pharmaceutical applications to protein misfolding diseases * Provides a comprehensive survey of many of the topics surrounding the universal biological aspects of protein misfolding * Includes a Foreword by R. John Ellis, International Gairdner Award Winner 2004 * Is coedited by Jeffery W. Kelly and Christopher M. Dobson, leaders in the field of protein biochemistry Protein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings--and bring hope one step closer to reality.